Irinotecan Impurity 23

Irinotecan Impurity 23 - Names and Identifiers

Name	1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
Synonyms	Irinotecan Impurity 23 1-CHLOROCARBONYL-4-PIPERIDINOPERIDINE 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE [1,4'-Bipiperidine]-1'-carbonyl chloride 4-Piperidinopiperidine-1-carbonyl chloride forMyl[4-(piperidin-1-yl)piperidin-1-yl]chloranuide
CAS	103816-19-9
EINECS	682-939-1

Irinotecan Impurity 23 - Physico-chemical Properties

Molecular Formula	C11H19ClN2O
Molar Mass	230.73
Density	1.184±0.06 g/cm3(Predicted)
Melting Point	60-64°C
Boling Point	344.5±31.0 °C(Predicted)
pKa	9.19±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

Irinotecan Impurity 23 - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 3261 8 / PGIII
WGK Germany	3

Irinotecan Impurity 23 - Introduction

Nature:
[1,4 '] Bipiperidine -1'-carboxylic acid chloride is a colorless or pale yellow liquid with a pungent odor. It has a high vapor pressure and solubility, and can be dissolved in a variety of organic solvents, such as ethanol, methanol and ether. It is a strongly acidic compound that reacts with bases to produce salts.

Use:
[1,4 '] Bipiperidine -1'-carbonyl chloride is commonly used as an intermediate in organic synthesis. It can be used to synthesize compounds such as pesticides, pharmaceuticals and dyes. In addition, it can also be used for acylation, acyl chlorination and acyl substitution in organic synthesis reactions.

Preparation Method:
The preparation of [1,4 '] bipiperidine -1'-carboxylic acid chloride is generally achieved by acylation of bipiperidine -1-amine. A common method is to use anhydrous formic acid as the acylating agent and to add an acidic catalyst, such as hydrochloric acid or sulfuric acid. The reaction is typically carried out at low temperature to yield [1,4 '] bipiperidine -1'-carboxylic acid chloride.

Safety Information:
Because [1,4 '] bipiperidine -1'-carbonyl chloride is irritating and corrosive, it is necessary to take appropriate safety measures during operation. Wear suitable protective gloves, goggles and protective clothing. Avoid contact with skin, eyes and respiratory tract. Operate in a well-ventilated area and avoid contact with combustibles.

Last Update：2024-04-09 21:04:16